Broken Chromosome Repair by Homologous Recombination • iBiology

4.1.1: Homologous recombination

PolyADP-ribose polymerase (PARP) plays a key role in the repair of DNA single-strand breaks. In the presence of the PARP inhibitor olaparib, single-strand breaks accumulate. When a replication fork encounters a single-strand break, it converts it to a double-strand break, which in normal cells is then repaired by homologous recombination. In cells defective for homologous recombination, however, inhibition of PARP triggers cell death. Patients who have only one functional copy of the Brcal gene,

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