The novel PDE10A inhibitor CPL'36 offers a new mechanism of action and is both safe and effective for acute exacerbations of schizophrenia, new research suggests.

Historically, 400 IU (10 ug) of vitamin D was recommended for better health because it closely approximated the amount of vitamin D in a teaspoonful of cod liver oil. However, 800 to 1,000 IU is ...

Purpose: A rare adverse effect observed after dose escalation of topiramate therapy is discussed. A review of published cases, monitoring recommendations, and important counseling information for ...

Authors and Disclosures Tim K Takaro 1, Kim Knowlton 2–4 and John R Balmes* 5,6 1 Faculty of Health Sciences, Simon Fraser University, 8888 University Dr., Burnaby, BC V5A 1S6, Canada 2 Natural ...

Rheumatoid arthritis is the most common etiology for inflammatory arthritis in the older population, with an estimated prevalence of 2%. An older individual with inflammatory polyarthritis usually ...

Aspirin is not only one of the best-documented medicines in the world, but also one of the most frequently used drugs of all times. In addition to its role as an analgesic, aspirin is being ...

Recently, ISMP Canada published a safety bulletin on oral dosing errors associated with LUGOL's solution (potassium iodide and iodine), also referred to as strong iodine solution. [1] The ...

Idiopathic normal pressure hydrocephalus (INPH) is a syndrome that is characterized by gait impairment, cognitive decline and urinary incontinence, and is associated with ventriculomegaly in the ...

The primary cicatricial alopecias are an uncommon, complex group of disorders that result in permanent destruction of the hair follicle, usually involving scalp hair alone. Prompt diagnosis and ...

Management of adverse events is a major concern of clinicians who use antipsychotic drugs. The incidence of motor side effects is dose dependent. Atypical antipsychotic drugs are less likely to ...

Harm Reduction Journal is an Open Access, peer-reviewed, online journal whose focus is prevalent patterns of psychoactive drug use, the public policies meant to control them, and the search for ...

Clobazam is the first and only 1,5-benzodiazepine in clinical use as an anticonvulsant. Clobazam exerts it anticonvulsant effects via its selective affinity for the ω 2 site of the GABA-A ...