Mahomes' record is 10-3 straight-up and 11-1-1 against the spread when he's starting and the Chiefs are underdogs.

Of course the 49ers want another shot at the Kansas City Chiefs, a replay of the Super Bowl in Las Vegas on what turned into ...

Preparation to face the Chiefs Sunday for the 49ers included film review of last season’s 25-22 overtime loss in Super Bowl ...

Eight months later, the pain of losing a second Super Bowl in five seasons to the Kansas City Chiefs has barely subsided for ...

Kyle Shanahan still plans to take Patrick Mahomes seriously in the 49ers' Week 7 showdown. Is Patrick Mahomes having a down ...

The latest NFL rumors involve a new Chiefs trade target, a potential Vikings upgrade, and the Raiders' outlook post-Davante Adams.

Neither Kyle Shanahan nor Nick Bosa ever has beaten Patrick Mahomes. Bosa is 0-3 against him and Shanahan is 0-4. So I asked them on Wednesday wh ...

Aside from outplaying the Chiefs quarterback, the 49ers third-year signal-caller has been radically different from a ...

And, um, I think we have the guys to do it. Ok. Thanks. Kansas City Chiefs head coach Andy Reid, quarterback Patrick Mahomes ...

The 49ers look to break a four-game losing streak against the Kansas City Chiefs since coach Kyle Shanahan took over as head ...

The Kansas City Chiefs didn't add to their receiver room during what was an eventful day of trades on Tuesday, but Patrick Mahomes is happy with the group ...

Chiefs QB Patrick Mahomes and Adidas collaborated with the Negro League Baseball Museum to make a shoe honoring the Kansas ...