Knocking out cell cycle protein in cancer cells was found to impair DNA repair mechanisms triggered by radiotherapy. Scientists suggest that blocking the cell cycle protein cyclin D1 in tumor cells ...
Characterization of OASEP1 as a biomarker and therapeutic target for oral cancer. Impact on U251 glioma cell radiosensitivity and CFL1 level via inhibiting cell motility regulator ROCKII of ...
Cyclins B1 and B2 are frequently elevated in human cancers and are associated with tumour aggressiveness and poor clinical outcome; however, whether and how B-type cyclins drive tumorigenesis is ...
Figure 1: Regulation of cell cycle processes by CDK–cyclin complexes. But what happens if a CDK–cyclin complex is present in the wrong place at the wrong time? Clearly, premature activation of a ...
This is a preview. Log in through your library . Abstract Phosphorylation of proteins on serine/threonine residues preceding proline is a key signaling mechanism. The conformation and function of a ...
This is a preview. Log in through your library . Abstract The retinoblastoma gene product (pRB) participates in the regulation of the cell division cycle through complex formation with numerous ...
Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder affecting roughly 1 in 3,500 males. DMD is due to mutations in the dystrophin gene, which encodes for an exceptionally large 427 kD ...
Survival data following phase 1/2 studies using precision tumor-targeted gene delivery to advanced chemotherapy-resistant malignancies. This is an ASCO Meeting Abstract from the ASCO Breakthrough: A ...
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