The acid dissociation constant, K a, and its negative decadic log, pK a, are key life sciences parameters that describe molecular acidity. Specifically, these values indicate the protonation state of ...

Scientists have developed a new nuclear magnetic resonance (NMR)-based method to measure the acidity (pKa) of “forever chemicals” (PFAS) and their breakdown products. Their results show that many PFAS ...

An illustration of a PFAS breakdown product in its negatively charged and neutral forms, depicted in a dynamic back-and-forth between these states. The accompanying chart illustrates a plot that ...

BUFFALO, N.Y. — One of the ways that per- and polyfluoroalkyl substances (PFAS) earn their “forever chemical” nickname and persist in the environment is their acidity. Many of these toxic chemicals ...

ABSTRACT: We here report a laboratory protocol for the determination of the pKa value of an acid by means of determinations obtained with a spectrophotometer. Students determine the acidity constant ...

Understanding the concept of pKa (the negative logarithm of the acid dissociation constant) is crucial for those who study chemistry, biochemistry, and other related fields. Knowing how to calculate ...

In the world of chemistry, equilibrium constants (Keq) and acid dissociation constants (pKa) play a vital role in understanding chemical reactions and their balance. The relationship between these two ...

The acid dissociation constant of drug active compounds (arylpropionic and aryl acetic acids) were determined in acetonitrile and water binary mixtures (corresponding volume fractions of 0.40, 0.45, 0 ...

Alzheimer's disease (AD) is a progressive neurological disorder, the most common form of dementia, characterized by memory loss and other intellectual abilities serious enough to interfere with daily ...