Lactylation is a reversible, covalent, post-translational modification of proteins. It occurs exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia.

Butovsky believes xenon has potential as an AD treatment. A Phase 1 clinical trial of xenon at BWH is recruiting healthy elderly volunteers to test safety and effects on immune cells. “I hope this ...

Atlas Overview. A survey of regulatory RNA used two cohorts (A), six brain regions (B), and four AD traits (D) to examine four types of RNA (C), turning up more than 25,000 differences between AD and ...