eLife52m
Dopamine activity encodes the changing valence of the same stimulus in conditioned taste aversion paradigms
This study utilizes an elegant approach to examine valence encoding of the mesolimbic dopamine system. The findings are valuable, demonstrating differential responses of dopamine to the same taste ...
eLife54m
Hierarchical Bayesian modeling of multi-region brain cell count data
We can now collect cell-count data across whole animal brains quantifying recent neuronal activity, gene expression, or anatomical connectivity. This is a powerful approach since it is a multi-region ...
eLife2h
Navigation: Building a cognitive map through self-motion
Mice can generate a cognitive map of an environment based on self-motion signals when there is a fixed association between their starting point and the location of their goal.
eLife2h
Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC
Department of Molecular Biology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka, Japan ...
eLife2h
Osterix Facilitates Osteocytic Communication by Targeting Connexin43
Given their non-migratory nature within the mineralized matrix, their unique dendrites are crucial for cell-to-cell communication in response to both intracellular and extracellular stimuli, such as ...
eLife2h
Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex
The prelimbic (PrL) cortex is vulnerable to insult from adolescent alcohol exposure and receives input from the basolateral amygdala (BLA) while sending projections to the ventrolateral periaqueductal ...
eLife2h
How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective
Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...
eLife3d
Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. The authors were attempting to identify the molecular and ...
eLife3d
Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest
In this valuable study, the authors used an elegant genetic approach to delete EED at the post-neural crest induction stage. The usage of the single-cell RNA-seq analysis method is extremely suitable ...
eLife3d
Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest
Department of Radiation Oncology, University of California San Francisco, San Francisco, USA Department of Neurosurgery, University of California San Francisco, San Francisco, USA Department of ...
eLife3d
Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies
This paper aims to understand why prostate cancer with CDK12 loss does not respond to HRd-based therapeutics, such as PARP inhibitors. The work is felt to be fundamental given a thorough computational ...