A Penn State upset of No. 1 Ohio State on the road. Possible? Yes. Unlikely? Also, yes. But let’s keep it positive for a Nittany Lions team trying to shock the world. PSU (3-4, 0-4) is hunting for a signature win.

Entering the 2025 season ranked No. 2 and expected to contend for a national title, the Penn State Nittany Lions instead slipped to a 3–4 overall record, 0-4 in Big Ten play, and watched their playoff hopes evaporate in real time.

Penn State's still looking for its first Big Ten win. Here's seven players looking to spoil Ohio State's impressive 2025 season.

Ethan Grunkemeyer grew up in a suburb of Columbus. Now he gets a chance to take down the Buckeyes on their own turf.

Despite a coordinator change and loss of most starters, Ohio State is allowing the fewest points per game in the FBS in 2025. Here's how.

Jim Knowles won a national championship with Ohio State last season, but the Buckeyes defense is even better this year.

The Nittany Lions quarterback grew up near Columbus among Buckeyes fans. He has dreamed of playing at Ohio Stadium.

Ohio State will pay tribute to two late players, Nick Mangold and Bob Maggs, before the Buckeyes kick off against Penn State on Nov. 1.