Chargers: OLB Khalil Mack (elbow) returned to practice this week following a stint on injured reserve, potentially putting him in line to be active on Sunday. WR Quentin Johnston (hamstring) is on track to return after being held out against Miami. RT Trey Pipkins III (knee) hasn’t practiced this week and could miss another game.

What worked offensively last against the struggling Dolphins (1-5) last weekend might not work against the Colts (5-1) on Sunday.

The Indianapolis Colts’ success this season has been one of the biggest stories of the 2025 NFL season. Indy is entering Week 7 with a 5-1 record and are looking like Super Bowl contenders.The offense has done it’s part this season by averaging 32.

Chargers Head Coach Jim Harbaugh speaks to the media at his press conference during Week 7 of the 2025 NFL season. He discusses injury updates for outside linebacker Khalil Mack, linebacker Denzel Perryman,

Shane Steichen’s journey to becoming head coach of the Indianapolis Colts began in 2011 as a defensive assistant with the Los Angeles Chargers, where he spent nine seasons in total.

The Indianapolis Colts have been money-printers this year. Here's where the value is against the Los Angeles Chargers.

If Johnston misses his second straight contest, rookie tight end Oronde Gadsden II could be featured in the passing game again. The fifth-round draft pick notched a season-high seven catches on eight targets for 68 yards against Miami, and the receptions were tied with McConkey for most on the team. Sunday’s game will start at 4:05 p.m. ET on CBS.

The Chargers aredealing with issues with personnel, performance and scheme. They must get them corrected with a big test awaiting.