A first reading of the results reveals that there is a change of enthalpy and entropy during the transition state corresponding to 20% approximately of the total measured in the folding.

So your freezer can lower the entropy in water by turning it into ice, as long as it increases the total entropy by emitting heat. But more fundamentally, there's a distinct difference between ...

Six possible sources of the large heat capacity and entropy changes frequently observed for processes involving proteins are identified. Of these the conformational, hydrophobic, and vibrational ...

Despite having a large enthalpy of mixing, these materials can surprisingly crystalize in a single crystal structure, enabled by the large configurational entropy in the lattice.