The Kremlin responded Monday to remarks by Israeli Prime Minister Netanyahu on possible Iranian regime change, issuing a condemnation of the "actions" that have led to escalated tensions between the two Middle Eastern nations.

The Iran regime is very weak,” Israeli Prime Minister Benjamin Netanyahu said in a television interview. Israeli struck energy facilities and government buildings Sunday.

Since Israel began its concerted attack on Iran on Friday, calls for regime change in Iran have grown louder – from hawks in the US Congress to Israeli officials and some Iranian activists abroad.

Russia is appealing to Israel to show restraint in the crisis with Iran, and believes Tehran is exercising its right to self-defence, Deputy Foreign Minister Sergei Ryabkov was quoted as saying on Monday.

This is the second time President Trump and Russian President Vladimir Putin have spoken on the phone this month.

President Trump urged Iran to return to negotiations over the future of its nuclear program to end conflict with Israel. “They should talk and they should talk immediately before it’s too late,” Trump told reporters on Monday in Canada,