Genetic model reveals a form of calcium release is unnecessary for normal muscle contraction

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...
EurekAlert!

Skeletal muscle tissue engineering: from tissue regeneration to biorobotics

A review paper by scientists at the University of Oxford highlights recent advancements in SMTE, including innovations in ...
EurekAlert!

New genetic model reveals calcium-induced calcium release is dispensable for skeletal muscle contraction

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...
Business Wire

Edgewise Therapeutics Announces Journal of Clinical Investigation Publication of Key Preclinical Data Linking Modulation of Fast Skeletal Muscle Contraction to Protection of ...

BOULDER, Colo.--(BUSINESS WIRE)--Edgewise Therapeutics, Inc., (Nasdaq: EWTX), a clinical-stage biopharmaceutical company focused on developing orally bioavailable, targeted, small molecule therapies ...