The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

The rapid advancement of artificial intelligence (AI) is transforming the field of structural biology. In May 2024, DeepMind and Isomorphic Labs launched AlphaFold 3 (AF3), a revolutionary AI system ...

Tumor necrosis factor ligand superfamily member 9 (4-1BBL), also known as 4-1BB ligand, CD137L, or TNFSF9, is a cytokine that binds to TNFRSF9. It serves as the high-affinity ligand for 4-1BB and ...

AlphaFold 3 (AF3), the latest AI model from Google DeepMind and Isomorphic Labs, can predict the structures and interactions ...

Affinity chromatography has emerged as an indispensable tool in modern protein purification, leveraging highly selective interactions between target proteins and immobilised ligands. This technique, ...

Researchers have discovered how unstructured segments of surface proteins regulate the biological function of a cell. Their ...

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However, whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The transmembrane E3 ubiquitin ...

SciSparc Ltd. (Nasdaq: SPRC) (the "Company" or "SciSparc"), a specialty clinical-stage pharmaceutical company focusing on the development of therapies to treat disorders of the central nervous system, ...

Pharma companies are collaborating to boost the power of artificial intelligence (AI) in drug discovery by allowing access to ...

Bruker Corporation BRKR recently received new orders for advanced Nuclear Magnetic Resonance (“NMR”) instrumentation from the New York Structural Biology Center (“NYSBC”), the University of Delaware ...

A new method that successfully designs serine hydrolase enzymes capable of catalyzing ester hydrolysis with high efficiency, demonstrates a computational approach for creating de novo enzymes that ...