According to the World Health Organization, 422 million adults across the globe have diabetes. To help the growing patient population, researchers are going down to the molecular level. Here, they're ...

March 12, 2004 -- Proinsulin is a very sensitive marker of beta cell exhaustion and may therefore be useful for therapeutic decision-making in type 2 diabetes, according to the results of a study ...

A high serum proinsulin level and a low insulin-like-growth-factor-binding protein 1 (IGFBP-1) level are predictors of cardiovascular disease and diabetes in obese adults, but little evidence exists ...

Proinsulin-transferrin (ProINS-Tf) fusion protein was evaluated for its in vivo pharmacokinetics, efficacy, and mechanism. Our previous studies have shown that ProINS-Tf was converted to active ...

Diabetic neuropathy is the most common microvascular complication of diabetes. Here we show that, in streptozotocin-induced diabetic rodents with neuropathy, a subpopulation of bone-marrow-derived ...

A new genetically modified form of proinsulin can reduce the autoimmune response against insulin in individuals with type 1 diabetes mellitus (T1DM) while preserving immune regulatory responses, a ...

Could cow milk be the new cure for diabetes? Researchers have genetically modified a brown cow in Brazil to produce human insulin in its milk, which marks a breakthrough in diabetes treatment research ...

THE protein hormone insulin seems to be of perennial interest to biochemists. It was among the first to be crystallized and was the first protein whose primary structure was elucidated by Sanger and ...

Childhood obesity, epidemic in the United States, has been accompanied by an increase in the prevalence of type 2 diabetes among children and adolescents. We determined the prevalence of impaired ...

Millions of people living with type 1 diabetes around the world don’t have reliable access to insulin. Due to their bodies’ inability to produce the hormone, they have to inject it to ensure that ...

In a recent study published in the Biotechnology Journal, a team of researchers from Brazil constructed a lentivirus vector with expression specific for mammary glands and carrying the gene for human ...

ANN ARBOR, Mich. - According to the World Health Organization, 422 million adults across the globe have diabetes. In fact, the number of adults with the disease continues to grow each year. To help ...