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Elevated Dickkopf 3 Promotes Abdominal Aortic Aneurysm Formation via Modulated Phenotype Switch of Vascular Smooth Muscle Cells
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disorder that primarily affects elderly males. It often develops asymptomatically, yet ...
Drug discovery approaches can be broadly divided into two categories – target-based and phenotypic screening. Historically, medicines were selected for their visible (or perceived) health benefits, ...
American Journal of Botany, Vol. 84, No. 11 (Nov., 1997), pp. 1542-1552 (11 pages) Patterns of phenotypic plasticity and genotypic variation in light response of growth and photosynthesis were ...
The ASHG president offers some meeting highlights and what she will be looking forward to next week in Boston.
Changes in cellular phenotype are important to cancer progression because these changes can facilitate tumor initiation and metastasis, immune invasion, chemoresistance and many other aspects of tumor ...
Today, nine out of ten drugs fail in clinical trials. Furthermore, it takes over a decade and an average cost of $2 billion to develop and approve each medicine. 1 An important underlying reason is ...
Many evolutionary studies require an understanding of phenotypic change. However, while analyses of phenotypic variation across pairs of evolutionary levels (populations or time steps) are well ...
The characteristics of an organism emerge through complex interactions of its genetic make-up and the effects of the environment. This article discusses this terminological distinction in genetics - ...
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