The protooncoprotein N-Myc, which is overexpressed in approximately 25% of neuroblastomas as the consequence of MYCN gene amplification, has long been postulated to regulate DNA double-strand break ...

Gene editing in plants remains challenging, with the traditional non-homologous end-joining (cNHEJ) repair pathway often hindering precision.

Poly adenosine diphosphate-ribose polymerase inhibitors, an important class of anticancer drugs, employ synthetic lethality strategy and are particularly effective against cancers with genetic ...