Cytochrome P450 enzymes constitute a superfamily of haem-containing proteins that catalyse the oxidation of a wide range of exogenous and endogenous compounds. Their function is fundamental to the ...

Phase I study of docetaxel and temsirolimus in refractory solid tumors. Background: Interactions of cytochrome P450 (CYP), especially CYP3A4, between chemotherapy agents and other xenobiotics can ...

Clinical pharmacologists have achieved major progress for improving the reliability of drugs. In a pharmacological study, they showed that interactions between drugs can be detected with minute doses ...

Ann Arbor, MI - The antiplatelet action of clopidogrel appears to be inhibited by the lipid-lowering agent atorvastatin, according to a new study. The authors note that the mechanism involved is ...

GUIDING PRINCIPLE: The principles used in identifying drug-food and drug-drug interactions should be applied to identifying possible dietary supplement-induced interactions with other bioactive ...

Alexis Garcia, PharmD, senior director of business development at Tabula Rasa HealthCare, outlines how cytochrome P450 enzymes can impact medication efficacy in patients taking multiple drugs. So the ...

A combination of at least three antiretroviral drugs is recommended. Antiretroviral agents can cause alterations the liver enzymes that are responsible for metabolizing many common medications. HIV ...