Covalent bonds, in which two atoms are bound together by sharing a pair of electrons, form the scaffolding that underpins the majority of organic compounds. In 1931, the Nobel Laureate Linus Pauling ...

Covalent drugs form irreversible bonds with electrophilic amino acids on protein targets, leading to prolonged inhibition and enhanced therapeutic efficacy. Since the discovery of aspirin, various ...

Over the past decade, covalent drug discovery has undergone a surge of interest driven by the approvals of targeted covalent drugs and the rise of technological advancements accelerating covalent drug ...