New research reveals that a fundamental process in bacterial gene regulation called sigma cycle, long thought to involve the release of a key protein, sigma factor, might not be universal, opening new ...

Researchers from Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, USA, report a modification wherein replacing the RNA strand of a heteroduplex oligonucleotide with DNA may ...

Antisense oligonucleotides (ASOs) are small, single-stranded molecules that can suppress the expression of targeted genes and thereby achieve therapeutic effects. However, many ASO-based drug ...

Article reviewed by Govind Kaigala, PhD at the University of British Columbia. Stay up to date on the latest science with Brush Up Summaries. In situ hybridization (ISH) is a molecular technique that ...

Next-generation sequencing (NGS) has made analyzing DNA faster and cheaper, with effects felt in the lab, clinic, and beyond. A set of newly-launched technologies are offering a twist on the chemistry ...

DNA, or deoxyribonucleic acid, is the hereditary material found in nearly all living organisms. It carries the genetic instructions for the development, functioning, growth, and reproduction of all ...

Scientists report measurement of electrical conductivity of single DNA molecules as a way of monitoring the formation of double-stranded DNA on a gold surface. In their latest article, they ...

Since the technique was first published in 2019, prime editing has grown with lightning speed, alongside hopes for what it can achieve. Prime editing uses specialized machinery consisting of a prime ...

The origins of life remain a major mystery. How were complex molecules able to form and remain intact for prolonged periods without disintegrating? A team has demonstrated a mechanism that could have ...