All cells within the same cancer are not the same. They all have genetic errors that turn them into tumor cells, but these errors are not identical. In each cancer, there are populations of cells with ...

Only one out of 10,000 potential chemicals that are evaluated for drug discovery ever reach the market, and 40% of the compounds that begin animal trials will fail due to toxicity. Therefore, ...

Evaluation of interferon-alfa 2b in a model of acute respiratory distress syndrome and pulmonary fibrosis induced by intratraqueal bleomycin in Wistar rats This is an ASCO Meeting Abstract from the ...

Compound efficacy, specificity, accuracy, and in vivo relevance are key drivers in the decision-making process for progressing drug candidates through the lead-optimization phase into clinical trials.

Coronavirus disease-2019 (COVID-19) remains a critical global health concern. We developed a fully automated, high-throughput competition immunoassay to elucidate how epitope recognition on the severe ...

Cell-based assays are used to study genes, proteins, and whole cellular functions, as well as the mechanisms that control them, by measuring specific cellular parameters. They have become an important ...

Cell migration is a key cellular process that drives major developmental programs. To mimic and mechanistically understand cell migration in these different contexts, different assays have been ...

The disposition of antibody-based therapeutics is generally determined by both target-mediated and non-target processes, the latter being an often-overlooked aspect. Target-independent liabilities can ...

Cellular assays provide researchers with powerful insights into biological processes, including wound healing. However, scratch assays, the staple cell-based screening method in wound healing research ...