ascopubs.org

Population Pharmacokinetics of the Novel Anticancer Agent E7070 During Four Phase I Studies: Model Building and Validation

PURPOSE: N-(3-Chloro-7-indolyl)-1,4-benzenedisulfonamide (E7070) is a novel sulfonamide anticancer agent currently in phase II clinical development for the treatment of solid tumors. Four phase I ...
technologynetworks

Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model

The two-compartment pharmacokinetic model described the mechanisms how human body handles with ingestion of NC-cyclodextrin complexes in gastrointestinal tract (GI), distribution in the blood (Plasma) ...
Medscape

Pharmacokinetics and Pharmacodynamics of Intranasal Versus Intravenous Fentanyl in Patients with Pain after Oral Surgery

Models were fitted to population data using NMQUAL (https://metruminstitute.org/index.html-validated installation of the NONMEM, version V, level 1.1; GloboMax ...
JSTOR Daily

Some Generalized Stochastic Compartment Models for Digesta Flow

Digesta flow models have been based on linear compartment theory that assumes exponential retention times, and on a generalized theory that incorporates nonexponential (Erlang) retention times (Matis, ...
Medscape

Pharmacokinetics and Pharmacodynamics of Intranasal Versus Intravenous Fentanyl in Patients with Pain after Oral Surgery

Twenty-four patients were randomized in the study. Two populations were defined in the protocol: intent-to-treat and per protocol. One patient (no. 16) withdrew from the trial after having received ...