The formation of mitotic chromosomes requires both compaction of chromatin and the resolution of replicated sister chromatids. Compaction occurs during mitotic prophase and prometaphase, and in ...
Mitotic chromosome condensation has fascinated biologists since Flemming's early illustrations of mitosis in the late nineteenth century. Now — 130 years later — chromatid condensation is ...
Sister chromatid exchanges (SCE) and chromosome aberrations were induced in nondividing CHO cells that had been arrested in their cell cycle by deprivation of the essential amino acid arginine. Cells ...
Chromosomes begin to condense, taking on the form that they are usually depicted in: four arms connected at a point. Each chromosome is, at this time, actually two identical copies. Each copy is ...
Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN) with ...
Research has identified a double function for the Drosophila Dmt protein in both establishing and maintaining cohesion whereby identical chromatids pair during DNA replication. Dmt localizes to ...
Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...
Research has elucidated how cells are almost blind to chromosome cohesion defects. The results uncovered how these defects, often associated with cancer development, congenital diseases and ...
When cells are irradiated with ionizing radiation, one of the readily observed effects is the production of chromosome aberrations. These aberrations of the genetic apparatus can lead to drastic ...
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