The catalytic mechanism of the reductive half reaction of the quinoprotein methanol dehydrogenase (MDH) is believed to proceed either through a hemiketal intermediate or by direct transfer of a ...

The catalytic isomerization of allylic alcohols represents a pivotal transformation in modern synthetic chemistry. Using transition metal complexes, this reaction converts readily available allylic ...

A polymorphism in the gene for alcohol dehydrogenase type 3 (ADH3) alters the rate of alcohol metabolism. We investigated the relation among the ADH3 polymorphism, the level of alcohol consumption, ...

Phospholipids have major roles in the structure and function of all cell membranes. Most integral membrane proteins from the large CDP-alcohol phosphatidyltransferase family are involved in ...

Areas of expertise I became interested in studying enzyme mechanisms as an undergraduate project student and have now spent several years using computational techniques to explore aspects of enzyme ...