The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air crashes into the Great Lakes and lake effect snow ramps up throughout the weekend.

In last week’s 38-10 blowout loss to the Green Bay Packers, the 49ers’ loss had little to do with the weather at Lambeau Field, also known as “The Frozen Tundra.” At kickoff, it was a calm 42 degrees and mostly cloudy in the typical chilly Midwest city.