Lowe and Moore were famously part of the “Brat Pack,” a group of young ’80s Hollywood It-stars, including Emilio Estevez, Anthony Michael Hall, Andrew McCarthy, Ally Sheedy, Judd Nelson, Molly Ringwald.

Lowe and Moore, who were both famously considered part of the “ Brat Pack ” of young Hollywood stars in the ’80s, also costarred in 1985’s St. Elmo’s Fire. During their conversation about the film, Ripa, 54, once again brought up Moore, 61.

Rob Lowe said that ‘hookups’ between the Brat Pack Members were ‘inevitable’ and shared that he and Demi Moore ‘briefly had a thing’

Rob Lowe talked about the couples that formed and broke apart while filming "St. Elmo's Fire," including his crush on Demi Moore.

Rob Lowe and Demi Moore’s on-screen chemistry was hard to resist — even for the actors. Lowe, 60, disclosed that he “briefly had a thing” with Moore, 61, in the ’80s while talking to Kelly Ripa this week on her podcast,