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Follow live updates as Iran retaliates after Israel strikes nuclear facilities. Stay informed with real-time news and developments.

In all, at least 20 senior commanders were killed, two regional sources said. The head of the Revolutionary Guards aerospace force was also reported to be among them.

The president had asked Israel to hold off. Now he’s scrambling to make a deal in negotiations that have become even more complex.

A US president who vowed to be a peacemaker has to handle a new Middle East crisis that strikes a blow to his diplomatic efforts.

The call comes as Trump has been trying to accelerate aid into Gaza and has been trying to persuade Iran to give up its nuclear program.

WASHINGTON (AP) — President Donald Trump on Monday appeared to undercut a proposal that was offered by his special envoy to Iran, saying he will insist that Tehran fully dismantle its nuclear enrichment program as part of any deal to ease crushing sanctions.

Iran launched a new wave of missiles at Israel on Saturday, killing several people in residential buildings, while Israel said it had struck nuclear infrastructure sites in Tehran.

Secretary of State Marco Rubio was the first to respond to the attack publicly with a statement Thursday evening — but others have yet to comment.

"By defending ourselves, we're also defending our Arab neighbors, our Arab friends in peace, Europe, [and] the United States, which helps us all the time in our defense."

Israel unleashed airstrikes across Iran for a third day and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country